Review



nanotube inhibitors  (MedChemExpress)


Bioz Verified Symbol MedChemExpress is a verified supplier
Bioz Manufacturer Symbol MedChemExpress manufactures this product  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 94
      Buy from Supplier

    Structured Review

    MedChemExpress nanotube inhibitors
    Hybrids enhance the immunosuppressive function of iDCs and their underlying mechanisms. Flow cytometry sorting and detection of proliferation(A) and PDL-1 levels in total iDCs(B) and the iDCs with obtaining hybrid membrane components(I) after co-culture with hybrids. Live-cell imaging observations revealed that hybrids influence iDCs through cell migration(C), <t>nanotube</t> interactions(D and G), efferocytosis(E), label tracking(F), and label pulling(H). The impact of CK636(J), Dynasore(K) and L778123(L) on the proportion of iDCs cells with hybrid membrane components (DiD + GFP + ) and PDL-1 levels. Data are represented as means±SD (n=3). **P<0.01, ***P<0.001 vs DC 24h in A(two-tailed t-test); ***P<0.001 vs DC and ### P<0.001 vs Hybrid+DC in B(One-way ANOVA Tukey’s multiple comparison); ***P<0.001 vs DC in I(two-tailed t-test); *P<0.05, **P<0.01 vs -IFN-γ/IL-1β and # P<0.05, ## P<0.01, ### P<0.001 vs <t>-CK636/-Dy/-L77</t> in J-L(two-tailed t-test).
    Nanotube Inhibitors, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/nanotube inhibitors/product/MedChemExpress
    Average 94 stars, based on 1 article reviews
    nanotube inhibitors - by Bioz Stars, 2026-02
    94/100 stars

    Images

    1) Product Images from "Construction, Phenotypic Characterization, and Immunomodulatory Function Study of BMSC-Macrophage Hybrid in vitro"

    Article Title: Construction, Phenotypic Characterization, and Immunomodulatory Function Study of BMSC-Macrophage Hybrid in vitro

    Journal: bioRxiv

    doi: 10.1101/2025.07.25.666751

    Hybrids enhance the immunosuppressive function of iDCs and their underlying mechanisms. Flow cytometry sorting and detection of proliferation(A) and PDL-1 levels in total iDCs(B) and the iDCs with obtaining hybrid membrane components(I) after co-culture with hybrids. Live-cell imaging observations revealed that hybrids influence iDCs through cell migration(C), nanotube interactions(D and G), efferocytosis(E), label tracking(F), and label pulling(H). The impact of CK636(J), Dynasore(K) and L778123(L) on the proportion of iDCs cells with hybrid membrane components (DiD + GFP + ) and PDL-1 levels. Data are represented as means±SD (n=3). **P<0.01, ***P<0.001 vs DC 24h in A(two-tailed t-test); ***P<0.001 vs DC and ### P<0.001 vs Hybrid+DC in B(One-way ANOVA Tukey’s multiple comparison); ***P<0.001 vs DC in I(two-tailed t-test); *P<0.05, **P<0.01 vs -IFN-γ/IL-1β and # P<0.05, ## P<0.01, ### P<0.001 vs -CK636/-Dy/-L77 in J-L(two-tailed t-test).
    Figure Legend Snippet: Hybrids enhance the immunosuppressive function of iDCs and their underlying mechanisms. Flow cytometry sorting and detection of proliferation(A) and PDL-1 levels in total iDCs(B) and the iDCs with obtaining hybrid membrane components(I) after co-culture with hybrids. Live-cell imaging observations revealed that hybrids influence iDCs through cell migration(C), nanotube interactions(D and G), efferocytosis(E), label tracking(F), and label pulling(H). The impact of CK636(J), Dynasore(K) and L778123(L) on the proportion of iDCs cells with hybrid membrane components (DiD + GFP + ) and PDL-1 levels. Data are represented as means±SD (n=3). **P<0.01, ***P<0.001 vs DC 24h in A(two-tailed t-test); ***P<0.001 vs DC and ### P<0.001 vs Hybrid+DC in B(One-way ANOVA Tukey’s multiple comparison); ***P<0.001 vs DC in I(two-tailed t-test); *P<0.05, **P<0.01 vs -IFN-γ/IL-1β and # P<0.05, ## P<0.01, ### P<0.001 vs -CK636/-Dy/-L77 in J-L(two-tailed t-test).

    Techniques Used: Flow Cytometry, Membrane, Co-Culture Assay, Live Cell Imaging, Migration, Two Tailed Test, Comparison



    Similar Products

    nanotube inhibitors  (MedChemExpress)
    94
    MedChemExpress nanotube inhibitors
    Hybrids enhance the immunosuppressive function of iDCs and their underlying mechanisms. Flow cytometry sorting and detection of proliferation(A) and PDL-1 levels in total iDCs(B) and the iDCs with obtaining hybrid membrane components(I) after co-culture with hybrids. Live-cell imaging observations revealed that hybrids influence iDCs through cell migration(C), <t>nanotube</t> interactions(D and G), efferocytosis(E), label tracking(F), and label pulling(H). The impact of CK636(J), Dynasore(K) and L778123(L) on the proportion of iDCs cells with hybrid membrane components (DiD + GFP + ) and PDL-1 levels. Data are represented as means±SD (n=3). **P<0.01, ***P<0.001 vs DC 24h in A(two-tailed t-test); ***P<0.001 vs DC and ### P<0.001 vs Hybrid+DC in B(One-way ANOVA Tukey’s multiple comparison); ***P<0.001 vs DC in I(two-tailed t-test); *P<0.05, **P<0.01 vs -IFN-γ/IL-1β and # P<0.05, ## P<0.01, ### P<0.001 vs <t>-CK636/-Dy/-L77</t> in J-L(two-tailed t-test).
    Nanotube Inhibitors, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/nanotube inhibitors/product/MedChemExpress
    Average 94 stars, based on 1 article reviews
    nanotube inhibitors - by Bioz Stars, 2026-02
    94/100 stars
    		  Buy from Supplier

    Image Search Results


    Hybrids enhance the immunosuppressive function of iDCs and their underlying mechanisms. Flow cytometry sorting and detection of proliferation(A) and PDL-1 levels in total iDCs(B) and the iDCs with obtaining hybrid membrane components(I) after co-culture with hybrids. Live-cell imaging observations revealed that hybrids influence iDCs through cell migration(C), nanotube interactions(D and G), efferocytosis(E), label tracking(F), and label pulling(H). The impact of CK636(J), Dynasore(K) and L778123(L) on the proportion of iDCs cells with hybrid membrane components (DiD + GFP + ) and PDL-1 levels. Data are represented as means±SD (n=3). **P<0.01, ***P<0.001 vs DC 24h in A(two-tailed t-test); ***P<0.001 vs DC and ### P<0.001 vs Hybrid+DC in B(One-way ANOVA Tukey’s multiple comparison); ***P<0.001 vs DC in I(two-tailed t-test); *P<0.05, **P<0.01 vs -IFN-γ/IL-1β and # P<0.05, ## P<0.01, ### P<0.001 vs -CK636/-Dy/-L77 in J-L(two-tailed t-test).

    Journal: bioRxiv

    Article Title: Construction, Phenotypic Characterization, and Immunomodulatory Function Study of BMSC-Macrophage Hybrid in vitro

    doi: 10.1101/2025.07.25.666751

    Figure Lengend Snippet: Hybrids enhance the immunosuppressive function of iDCs and their underlying mechanisms. Flow cytometry sorting and detection of proliferation(A) and PDL-1 levels in total iDCs(B) and the iDCs with obtaining hybrid membrane components(I) after co-culture with hybrids. Live-cell imaging observations revealed that hybrids influence iDCs through cell migration(C), nanotube interactions(D and G), efferocytosis(E), label tracking(F), and label pulling(H). The impact of CK636(J), Dynasore(K) and L778123(L) on the proportion of iDCs cells with hybrid membrane components (DiD + GFP + ) and PDL-1 levels. Data are represented as means±SD (n=3). **P<0.01, ***P<0.001 vs DC 24h in A(two-tailed t-test); ***P<0.001 vs DC and ### P<0.001 vs Hybrid+DC in B(One-way ANOVA Tukey’s multiple comparison); ***P<0.001 vs DC in I(two-tailed t-test); *P<0.05, **P<0.01 vs -IFN-γ/IL-1β and # P<0.05, ## P<0.01, ### P<0.001 vs -CK636/-Dy/-L77 in J-L(two-tailed t-test).

    Article Snippet: To clarify the mechanism of membrane transfer between the two cell types, the hybrids were treated with nanotube inhibitors (L-778123, L77, MCE, HY-16273) and migrasome inhibitors (Dynasore, Dy, MCE HY-15304 and CK636, MCE HY-15892) for 8 hours prior to being co-cultured with iDCs for another 24 hours.

    Techniques: Flow Cytometry, Membrane, Co-Culture Assay, Live Cell Imaging, Migration, Two Tailed Test, Comparison